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RNAstructure: software for RNA secondary structure prediction and analysis | BMC Bioinformatics | Full Text
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Background To understand an RNA sequence
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pubmed, article, google, scholar, structure, rna, cas, prediction, secondary, central, dna, mathews, sequence, parameters, rnastructure, structures, energy, nucleic, thermodynamic, sequences, biochemistry, acids, res, free, class, thermodynamics, java, interfaces, stability, text, gui, bmc, turner, base, windows, analysis, bioinformatics, nar, bia, authors, library, algorithms, interface, figure, data, package, methods, classes, pairs, lowest,
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t-a-t-t-a-a-t-a-t-c-a-a-g-t-t c-a-a-c-t-t-g-a-t-a-t-t-a-a-t springer nature conclusions rnastructure allawi ht nearest-neighbor energy parameters expanded nearest-neighbor model single base-pair mismatches project home page author information authors linux/unix shared libraries unix/linux text-based interfaces java-based graphical interface compensating base pair background multi-helix junction loops single-sequence structure prediction authors scientific editing base pair probabilities cold spring harbor received increasing attention gc base pair privacy choices/manage cookies unix-style text interfaces nearest neighbor rules secondary structure prediction free energy change user-friendly interface nearest neighbor parameters free energy minimization free-energy minimization rna/dna hybrid duplexes secondary structure common havgaard jh authorsβ original file interface functions cross-platform moody em rnastructure code download small interfering rnas van boom jh nearest-neighbor thermodynamics biomed central rna secondary structure implementation implementation page rdm unusually stable rna dna-rna hybridization parameters bimolecular structure prediction base-base mismatches
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headline:RNAstructure: software for RNA secondary structure prediction and analysis
description:To understand an RNA sequence's mechanism of action, the structure must be known. Furthermore, target RNA structure is an important consideration in the design of small interfering RNAs and antisense DNA oligonucleotides. RNA secondary structure prediction, using thermodynamics, can be used to develop hypotheses about the structure of an RNA sequence. RNAstructure is a software package for RNA secondary structure prediction and analysis. It uses thermodynamics and utilizes the most recent set of nearest neighbor parameters from the Turner group. It includes methods for secondary structure prediction (using several algorithms), prediction of base pair probabilities, bimolecular structure prediction, and prediction of a structure common to two sequences. This contribution describes new extensions to the package, including a library of C++ classes for incorporation into other programs, a user-friendly graphical user interface written in JAVA, and new Unix-style text interfaces. The original graphical user interface for Microsoft Windows is still maintained. The extensions to RNAstructure serve to make RNA secondary structure prediction user-friendly. The package is available for download from the Mathews lab homepage at
http://rna.urmc.rochester.edu/RNAstructure.html
.
datePublished:2010-03-15T00:00:00Z
dateModified:2010-03-15T00:00:00Z
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license:http://creativecommons.org/licenses/by/2.0
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keywords:
Structure Prediction
Secondary Structure Prediction
Class Library
Neighbor Parameter
Base Pair Probability
Bioinformatics
Microarrays
Computational Biology/Bioinformatics
Computer Appl. in Life Sciences
Algorithms
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headline:RNAstructure: software for RNA secondary structure prediction and analysis
description:To understand an RNA sequence's mechanism of action, the structure must be known. Furthermore, target RNA structure is an important consideration in the design of small interfering RNAs and antisense DNA oligonucleotides. RNA secondary structure prediction, using thermodynamics, can be used to develop hypotheses about the structure of an RNA sequence. RNAstructure is a software package for RNA secondary structure prediction and analysis. It uses thermodynamics and utilizes the most recent set of nearest neighbor parameters from the Turner group. It includes methods for secondary structure prediction (using several algorithms), prediction of base pair probabilities, bimolecular structure prediction, and prediction of a structure common to two sequences. This contribution describes new extensions to the package, including a library of C++ classes for incorporation into other programs, a user-friendly graphical user interface written in JAVA, and new Unix-style text interfaces. The original graphical user interface for Microsoft Windows is still maintained. The extensions to RNAstructure serve to make RNA secondary structure prediction user-friendly. The package is available for download from the Mathews lab homepage at
http://rna.urmc.rochester.edu/RNAstructure.html
.
datePublished:2010-03-15T00:00:00Z
dateModified:2010-03-15T00:00:00Z
pageStart:1
pageEnd:9
license:http://creativecommons.org/licenses/by/2.0
sameAs:https://doi.org/10.1186/1471-2105-11-129
keywords:
Structure Prediction
Secondary Structure Prediction
Class Library
Neighbor Parameter
Base Pair Probability
Bioinformatics
Microarrays
Computational Biology/Bioinformatics
Computer Appl. in Life Sciences
Algorithms
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