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Title[redir]:
Reactive oxygen species activate a Ca2+-dependent cell death pathway in the unicellular organism Trypanosoma brucei brucei - PMC
Description:
Here we examine a cell death process induced by reactive oxygen species (ROS) in the haemoflagellate Trypanosoma brucei brucei. Ca2+ distribution in cellular compartments was measured with stable transformants expressing aequorin targeted to the ...
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Keywords {🔍}
doi, pubmed, google, scholar, cell, trypanosoma, brucei, pmc, article, calcium, free, biol, death, apoptosis, nlm, biochem, ruben, oct, human, chem, trypanosomes, dec, parasitol, ncbi, search, nuclear, mol, jul, serum, ros, bcl, cruzi, docampo, exp, xiong, induced, targeted, mitochondrion, dna, references, programmed, differ, nitric, immunol, hajduk, african, mar, jbc, reactive, oxygen,
Topics {✒️}
c-terminal targeting signal cytosolic-free calcium elevation n-methyl-d-aspartate 5-trisphosphate-sensitive ca2+ release pmc beta search calmodulin-stimulated ca2+ pump human haptoglobin-related protein nitric oxide-mediated suppression high density lipoprotein naturally resistant cattle cytotoxic human hdl human serum sensitive normal human serum reactive oxygen species full text billaut-mulot main lytic factor haptoglobin-related protein license information pmcid soluble trypanosome products free radicals unicellular organism leishmania african buffalo serum accumulate ca2+ efficiently excess ca2+ accumulated pmc disclaimer united states government egta acetoxymethyl ester nitric oxide/superoxide skeletal muscle myotubes streptococcus sanguis expresses heat shock induction biochim biophys acta nitric oxide synthase mitochondrial ca2+ transport intracellular ca2+ buffer trypanosoma brucei infection slender bloodstream forms programmed cell death cell death differ trypanosoma brucei brucei selected references trypanosoma cruzi infectivity annu rev microbiol nuclear dna occurred independent adhesin epitopes african trypanosomiasis inhibit prevented dna fragmentation arch med res nuclear calcium flux
Questions {❓}
- The central executioners of apoptosis: caspases or mitochondria?
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