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Title:
Reactive oxygen species activate a Ca2+-dependent cell death pathway in the unicellular organism Trypanosoma brucei brucei. - PMC
Description:
Here we examine a cell death process induced by reactive oxygen species (ROS) in the haemoflagellate Trypanosoma brucei brucei. Ca2+ distribution in cellular compartments was measured with stable transformants expressing aequorin targeted to the cytosol, ...
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Keywords {π}
pubmed, google, scholar, cell, trypanosoma, brucei, pmc, article, calcium, biol, free, death, apoptosis, biochem, ruben, human, chem, oct, trypanosomes, parasitol, dec, nuclear, jul, serum, mol, nlm, ros, bcl, exp, docampo, cruzi, main, xiong, induced, targeted, mitochondrion, dna, nitric, immunol, mar, african, hajduk, programmed, differ, ncbi, search, reactive, oxygen, species, unicellular,
Topics {βοΈ}
c-terminal targeting signal cytosolic-free calcium elevation n-methyl-d-aspartate 5-trisphosphate-sensitive ca2+ release main lytic factor calmodulin-stimulated ca2+ pump main content human haptoglobin-related protein nitric oxide-mediated suppression high density lipoprotein naturally resistant cattle cytotoxic human hdl normal human serum human serum sensitive reactive oxygen species pmc disclaimer haptoglobin-related protein welburn sc soluble trypanosome products african buffalo serum ben-sasson sa unicellular organism leishmania accumulate ca2+ efficiently excess ca2+ accumulated united states government egta acetoxymethyl ester nitric oxide synthase otieno-omondi fp streptococcus sanguis expresses nitric oxide/superoxide biochim biophys acta skeletal muscle myotubes del portillo ha heat shock induction mitochondrial ca2+ transport intracellular ca2+ buffer free radicals trypanosoma brucei infection slender bloodstream forms programmed cell death cell death differ trypanosoma brucei brucei trypanosoma cruzi infectivity annu rev microbiol nuclear dna occurred mol biochem parasitol pmc website african trypanosomiasis inhibit independent adhesin epitopes prevented dna fragmentation
Questions {β}
- The central executioners of apoptosis: caspases or mitochondria?
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